MT-2 (10mg)

Product Overview

Melanotan II (MT-2) is a synthetic cyclic heptapeptide (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂) analog of the endogenous tridecapeptide alpha-melanocyte-stimulating hormone (α-MSH). The cyclic structure and D-phenylalanine substitution confer enhanced metabolic stability and receptor binding affinity relative to the linear native hormone.

Specifications

• Quantity: 10mg lyophilized powder
• Purity: ≥98% (HPLC verified)
• Manufacturing: Produced in a GMP-compliant facility in the USA
• Molecular Weight: 1,024.2 Da
• Sequence: Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
• Appearance: White lyophilized powder
• Solubility: Soluble in water

Storage & Handling

• Store at -20°C for long-term storage
• Stable at 2-8°C for up to 30 days after reconstitution
• Protect from light
• Reconstitute with bacteriostatic water

Mechanism of Action

MT-2 is a non-selective agonist at melanocortin receptors MC1R through MC5R. Binding to MC1R on melanocytes activates Gαs/adenylyl cyclase/cAMP signaling, which phosphorylates CREB and upregulates transcription of the MITF gene — the master regulator of melanogenesis. MITF drives expression of tyrosinase and tyrosinase-related proteins (TRP-1, TRP-2) that catalyze the conversion of L-tyrosine to melanin intermediates (DOPA, dopaquinone) and ultimately eumelanin. MC3R and MC4R activation in hypothalamic nuclei modulates downstream signaling through the leptin-melanocortin axis.

For Laboratory Use Only. Laboratory Use Only.

Quality Assurance: Each lot undergoes independent third-party LCMS/MS analysis. Certificates of Analysis are available on the product page.