TB-500 (10mg)

Product Overview

TB-500 is the synthetic version of Thymosin Beta-4 (Tβ4), a 43-amino acid peptide (molecular formula: C₂₁₂H₃₅₀N₅₆O₇₈S) first isolated from the thymus gland. It is one of the most abundant members of the beta-thymosin family and is found in virtually all nucleated cells. TB-500 is characterized by its central actin-binding domain (amino acids 17-23: LKKTETQ), which mediates its primary interaction with monomeric G-actin.

Specifications

• Quantity: 10mg lyophilized powder
• Purity: ≥98% (HPLC verified)
• Manufacturing: Produced in a GMP-compliant facility in the USA
• Molecular Weight: 4,963 Da
• Sequence Length: 43 amino acids
• Appearance: White lyophilized powder
• Solubility: Soluble in water

Storage & Handling

• Store at -20°C for long-term storage
• Stable at 2-8°C for up to 21 days after reconstitution
• Protect from light
• Reconstitute with bacteriostatic water

Mechanism of Action

TB-500 sequesters G-actin monomers via its LKKTETQ binding motif, modulating the G-actin/F-actin equilibrium and influencing cytoskeletal reorganization, cell migration, and organelle trafficking. Beyond actin regulation, Tβ4 interacts with the PINCH-1/ILK/parvin complex involved in integrin-linked kinase signaling and has been shown to modulate NF-κB-mediated inflammatory gene transcription. The N-terminal tetrapeptide fragment (Ac-SDKP) generated by enzymatic cleavage via prolyl oligopeptidase is itself biologically active in regulating fibroblast differentiation.

For Laboratory Use Only. Laboratory Use Only.

Quality Assurance: Each lot undergoes independent third-party LCMS/MS analysis. Certificates of Analysis are available on the product page.