SLU-PP-332

Product Overview

SLU-PP-332 is a small-molecule agonist of the estrogen-related receptor (ERR) family, with primary activity at ERRα and ERRγ subtypes. Despite the naming convention, ERRs are orphan nuclear receptors with no significant binding affinity for estrogen. They function as constitutive transcription factors regulating genes involved in mitochondrial biogenesis, oxidative phosphorylation, and fatty acid metabolism.

Specifications

• Form: Oral tablets
• Purity: ≥98% (third-party verified)
• Manufacturing: Produced in a GMP-compliant facility in the USA
• Molecular Formula: C₂₇H₂₃NO₄
• Molecular Weight: 425.48 g/mol
• CAS Number: 2070014-85-0
• Targets: ERRα (EC₅₀ ~0.37 μM), ERRγ

Storage & Handling

• Store at room temperature (15-25°C)
• Keep in original sealed container
• Protect from moisture and direct sunlight

Mechanism of Action

SLU-PP-332 binds to the ligand-binding domain of ERRα and ERRγ, stabilizing the receptor in an active conformation and enhancing coactivator recruitment (particularly PGC-1α). This promotes transcription of target genes involved in mitochondrial biogenesis (TFAM, NRF1), oxidative metabolism (PDK4, CPT1B, MCAD), and energy substrate utilization. ERR activation drives a transcriptional program that shifts cellular metabolism toward oxidative phosphorylation and fatty acid oxidation over glycolysis.

For Laboratory Use Only. Laboratory Use Only.