Product Overview
Nicotinamide adenine dinucleotide (NAD+) is a critical coenzyme found in every living cell. It serves as a primary electron carrier in oxidative phosphorylation and functions as a substrate for NAD-consuming enzymes, including sirtuins (SIRT1-7), poly(ADP-ribose) polymerases (PARPs), and CD38/CD157 ectoenzymes.
Specifications
- Quantity: 500mg lyophilized powder
- Purity: ≥98% (HPLC verified)
- Manufacturing: Produced in a GMP-compliant facility in the USA
- Molecular Weight: 663.43 g/mol
- Molecular Formula: C₂₁H₂₇N₇O₁₄P₂
- CAS Number: 53-84-9
- Appearance: White to off-white lyophilized powder
- Solubility: Soluble in water and PBS
Storage & Handling
- Store at -20°C for long-term storage
- Stable at 2-8°C for up to 30 days after reconstitution
- Protect from light and repeated freeze-thaw cycles
- Reconstitute with bacteriostatic water or sterile saline
Mechanism of Action
NAD+ participates in two primary classes of biochemical reactions: (1) as a coenzyme in redox reactions, shuttling electrons via the NAD+/NADH couple in glycolysis, the TCA cycle, and the electron transport chain; and (2) as a consumed substrate in enzymatic reactions catalyzed by sirtuins, PARPs, and cyclic ADP-ribose synthases. These pathways regulate cellular energy metabolism, DNA repair, gene expression, and calcium signaling.
For Laboratory Use Only. Laboratory Use Only.
Quality Assurance: Each lot undergoes independent third-party LCMS/MS analysis. Certificates of Analysis are available on the product page.
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