Product Overview
MOTS-C is a 16-amino acid peptide (MRWQEMGYIFYPRKLR) encoded within the 12S rRNA gene of the mitochondrial genome. It is the first mitochondrial-derived peptide (MDP) shown to translocate to the cell nucleus and directly regulate nuclear gene expression, establishing a retrograde signaling pathway from mitochondria to the nuclear genome.
Specifications
- Quantity: 10mg lyophilized powder
- Purity: ≥98% (HPLC verified)
- Manufacturing: Produced in a GMP-compliant facility in the USA
- Molecular Weight: 2,174.6 Da
- Sequence: MRWQEMGYIFYPRKLR (16 aa)
- Appearance: White to off-white lyophilized powder
- Solubility: Soluble in water
Storage & Handling
- Store at -20°C for long-term storage
- Stable at 2-8°C for up to 21 days after reconstitution
- Protect from light and repeated freeze-thaw cycles
- Reconstitute with bacteriostatic water
Mechanism of Action
MOTS-C activates the AMPK pathway by inhibiting the folate-methionine cycle, specifically targeting the enzyme MTHFD2 in de novo purine biosynthesis. This leads to accumulation of the intermediate AICAR, a known endogenous AMPK activator. AMPK activation subsequently modulates downstream targets including ACC (fatty acid synthesis), mTORC1 (protein synthesis), and GLUT4 translocation (glucose uptake). Under metabolic stress, MOTS-C translocates from the cytoplasm to the nucleus where it interacts with transcription factors (ARE-Nrf2 and FOXO1) to regulate adaptive gene expression programs involved in cellular stress response.
For research use only. Not for human consumption.
Quality Assurance: Each lot undergoes independent third-party LCMS/MS analysis. Certificates of Analysis are available on the product page.
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