GHK-Cu (100mg)

Product Overview

GHK-Cu is a naturally occurring tripeptide (Gly-His-Lys) with high affinity for copper(II) ions. First isolated from human plasma in 1973, GHK-Cu concentrations in plasma decline significantly with age. The peptide-copper complex functions as a pleiotropic signaling molecule involved in extracellular matrix remodeling, metalloenzyme activity, and gene expression regulation.

Specifications

• Quantity: 100mg lyophilized powder
• Purity: ≥98% (HPLC verified)
• Manufacturing: Produced in a GMP-compliant facility in the USA
• Molecular Weight: 403.93 g/mol (copper complex)
• Molecular Formula: C₁₄H₂₃N₆O₄Cu
• Sequence: Gly-His-Lys:Cu²⁺
• Appearance: Blue to blue-violet lyophilized powder
• Solubility: Freely soluble in water

Storage & Handling

• Store at -20°C for long-term storage
• Stable at 2-8°C for up to 30 days after reconstitution
• Protect from light
• Reconstitute with bacteriostatic water

Mechanism of Action

GHK-Cu modulates gene expression across multiple pathways — transcriptomic analysis has identified over 4,000 genes regulated by this tripeptide. Key mechanisms include: (1) delivery of copper ions to lysyl oxidase, which catalyzes collagen and elastin crosslinking in the extracellular matrix; (2) regulation of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs), controlling ECM turnover; (3) modulation of TGF-β superfamily signaling, influencing fibroblast differentiation and decorin expression; (4) SOD and glutathione system upregulation via copper-dependent enzyme activation. GHK-Cu also suppresses expression of NF-κB and its downstream inflammatory targets (IL-6, TNF-α).

For Laboratory Use Only. Laboratory Use Only.

Quality Assurance: Each lot undergoes independent third-party LCMS/MS analysis. Certificates of Analysis are available on the product page.