Product Overview
A dual-agonist peptide construct designed with bifunctional binding capabilities targeting both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor systems. The molecule incorporates structural elements from both native ligands, optimized for balanced co-agonism at both receptor subtypes.
Specifications
- Quantity: 10mg lyophilized powder
- Purity: ≥98% (HPLC verified)
- Manufacturing: Produced in a GMP-compliant facility in the USA
- Targets: GIP receptor (GIPR) and GLP-1 receptor (GLP-1R)
- Appearance: White to off-white lyophilized powder
- Solubility: Soluble in water and PBS
Storage & Handling
- Store at -20°C for long-term storage
- Stable at 2-8°C for up to 21 days after reconstitution
- Protect from light
- Reconstitute with bacteriostatic water
Mechanism of Action
The dual agonist simultaneously engages two class B GPCRs: GLP-1R and GIPR. GLP-1R activation drives Gαs/cAMP/PKA signaling in beta cells, brainstem, and hypothalamic nuclei. GIPR activation provides complementary signaling — in beta cells, GIPR couples to Gαs to enhance cAMP production and potentiate glucose-stimulated insulin secretion via a mechanism additive to GLP-1R activation. In adipose tissue, GIPR modulates lipid storage and adipokine secretion pathways. The combined engagement produces a broader signaling profile than single-receptor agonism by activating overlapping but distinct intracellular cascades across multiple tissue types.
For Laboratory Use Only. Laboratory Use Only.
Quality Assurance: Each lot undergoes independent third-party LCMS/MS analysis. Certificates of Analysis are available on the product page.
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